In an attempt to better manage overweight and obesity to help prevent diabetes and other diseases, there is much focus on reducing body weight, body fat and the risk of metabolic disease, with little attention to possible long-term adverse effects of weight loss interventions. However, with the expansion of obesity in all age groups in Australia and other countries, as well as increasing life expectancy, it is important to consider potential long-term effects of diet-induced weight loss and energy restriction. Of particular concern are the potential adverse effects of these obesity interventions on neuroendocrine status and body composition.
Energy deficit in lean or obese animals or humans stimulates appetite and reduces energy expenditure, thereby contributing to weight regain. Often overlooked in obesity interventions, however, is the effect of energy restriction on neuroendocrine status, and the impact this could have on body composition and strength.
This breakfast session covers hypothalamic pathways that could influence bone mass and muscle strength during diet-induced weight loss in overweight or obese humans and animals, notably via effects on circulating concentrations of hormones such as peptide YY or cortisol. It also highlights gaps in current knowledge and ideas for future research efforts.
As our population becomes increasingly obese, from a younger age, with more people using weight management strategies for longer, this line of enquiry could guard against inadvertent increases in frailty, fractures and loss of independence in our ageing population.
Assoc Prof Amanda Salis and team (Ms Jessica Zibellini, Ms Amy D Nguyen)
14:00 Introduction S Andrikopoulos
14:05 The art of scientific writing P Ebeling
14:20 The peer review process D Wilhelm
14:35 Responding to reviewer comments J Greenfield
14:50 Publishing ethics: Fabrication, Falsification and Plagiarism A Clark
15:05 Questions and discussion
2:00-2:15 Dr Kelly Walton (MIMR-PHI): “Generating specific TGF-b superfamily antagonists”
2:15-2:30 Dr Paul Gregorevic (Baker IDI): "Exploring Bone Morphogenetic Protein signalling as a positive regulator of skeletal muscle in health and disease"
2:30-2:45 Prof Frank Lovicu (University of Sydney): "Regulation of TGF-b for maintenance of lens and prevention of cataract."
2:45-3:00 Prof Ray Rodgers (Robinson Research Institute): “TGF-b and polycystic ovary syndrome”
3:00-3:15 Dr Phillip Kantharidis (Baker IDI): “TGF-b regulated microRNA in diabetic nephropathy”
3:15-3:30 Alistair Cole (PhD Student, University of Melbourne): “The Role of BMP Signalling in Oligodendrocyte Differentiation and Myelin Repair”
5 min break
3:35-3:50 Prof Peter Koopman (University of Queensland): “Nodal signalling in male germ cell development and testicular cancer”
3:50-4:00 Prof Kate Loveland (Monash University): “Hanging drop cultures reveal activin regulation of a key signalling molecule in human testicular germ cell tumours”
4:00-4:15 Dr Kaye Stenvers (MIMR-PHI): “TGFBR3 in reproductive development and cancer”
4:15-4:30 Dr Hitesh Peshavariya (Centre for Eye Research Australia): “Transforming growth factor-β1 requires NADPH oxidase-derived redox signalling for neovascularization”
4:30-4:45 Dr Hong-Jian Zhu (University of Melbourne): “Double edged sword: TGF-b signalling in breast cancer metastasis and implication in targeted therapy”
4:30-4:45 Prof David de Kretser (MIMR-PHI/Monash University): “The potential uses of follistatin in organ transplantation”
4:45-5:00 Dr Vicky Tsai (St Vincent’s Centre for Applied Medical Research): “MIC-1/GDF15, role in physiological and pathological regulation of appetite and body weight”