Oral Presentation The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2014

Vitamin D in muscle (#165)

Jenny Gunton 1
  1. University of Sydney, Westmead, NSW, Australia

It has long been recognised that vitamin D deficiency is associated with muscle weakness, which resolves with treatment of low vitamin D. However, the mechanisms behind this remain controversial, including the even whether the vitamin D receptor (VDR) itself is even expressed in muscle in adults.

Using whole-body vitamin D receptor null, and normal mice, tissue specific mice, and a validated model of vitamin D deficiency, we show that vitamin D is expressed in muscle in normal mice. The effects of abnormal vitamin D signalling in muscle will be discussed, and implications for therapy of muscle disorders.