Prof Clarke obtained his PhD at Edinburgh University in 1976. He held a research position at Prince Henry’s Institute from 1999 until 2005, conducting research in neuroendocrinology. He moved to Dept Physiology Monash University in 2005 and became Chairman in 2007. Prof Clarke has established an international profile in the field of Neuroendocrinology and has published 445 research papers. He is best known for his hypophysial portal access model that allows measurement of real-time in vivo secretions of the hypothalamus. He has contributed extensively to the field of neuroendocrinology for 35 years. In particular, his work has utilised sheep models, which allow a range of studies not easily undertaken in small laboratory species. He has developed a number of novel neuroendocrine methodologies that allow analysis ranging from the whole animal down to the single cell and subcellular function. These techniques have enabled a range of national and international collaborations, with grant funding from Australian and offshore sources. In addition, his laboratory undertakes a range of contract research projects.
His laboratory is currently focused on the following areas:
- Central regulation of reproduction by kisspeptin and gonadotropin inhibitory hormone
- Estrogen signalling in neuroendocrine systems
- Control of food intake and energy expenditure by leptin and novel regulatory factors
- Melanocortins and reproduction
- Central regulation of energy expenditure
Abstracts this author is presenting: