Oral Presentation The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2014

Co-targeting RNA Pol I and PIM kinase activity suppresses MYC-driven tumorigenesis in the prostate.  (#93)

Richard J Rebello 1 , Donald Cameron 2 , Gail P Risbridger 1 , Richard B Pearson 2 , Ross D Hannan 2 , Luc Furic 1
  1. Monash University, Melbourne, VIC, Australia
  2. Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
Publish consent withheld
  1. Bywater, MJ., Pearson, RB., McArthur, G., Hannan, R. Dysregulation of the basal RNA polymerase transcription apparatus in cancer. 2013. Nat Rev Cancer.
  2. Wang, J., Kim, J., Roh, M., Franco, OE., Hayward, SW., Willis, ML., Abdulkadir, SL. Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma. 2010. Oncogene.
  3. Wang, J., Anderson, PD., Luo, W., Gius, D., Roh, M., Abdulkadir, SL. Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells. 2012. Oncogene.
  4. Bywater, MJ., Poortinga, G., Sanij, G., Hein, N., Peck, A., Cullinane, C., Wall, M., Cluse, L., Drygin, D., Anderes, K., Huser, N., Proffitt, C., Bliesath, j., Haddach, M., Shwaebe, MK., Ryckman, DM., Rice, WG., Shmidt, C., Lowe, SW., Johnstone, RW., Pearson, RB., McArthur, GA., Hannan, RD. Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. 2012. Cancer Cell.